Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.7
USERS' SCORE
Good
Based on 7 Reviews
8.2
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Vitamin D3 (as cholecalciferol)
125 mcg
625%
Vitamin K activity from:Vitamin K1 (as phytonadione)Vitamin K2 (as menaquinone-4)Vitamin K2 (as trans menaquinone-7)
2,100 mcg1,000 mcg1,000 mcg100 mcg
1,750%
Iodine [from Sea-Iodine™ Complex Blend (organic kelp and bladderwrack extracts, potassium iodide)]
1,000 mcg
667%
Top Medical Research Studies
9
We conducted a study to understand how vitamin D3 influences lung cancer, particularly focusing on a protein known as histidine-rich calcium-binding protein (HRC). Our research explored whether vitamin D3 could help lower HRC levels, given its crucial role in calcium balance, which is significant in cancer development.
We measured the expression of HRC and the vitamin D receptor (VDR) in lung cancer tissues compared to normal and adjacent non-cancerous tissues. Using various lab techniques, we assessed how vitamin D3 affects lung cancer cells, including their growth, spread, and ability to undergo programmed cell death, known as apoptosis.
Our findings revealed that vitamin D3 does inhibit the expression of HRC, which in turn decreased the migration and proliferation of lung cancer cells. Additionally, we noted an increase in the number of cells undergoing apoptosis in response to vitamin D3 treatment. In our animal model, mice treated with a vitamin D3 formulation exhibited smaller tumors and fewer cancerous cells than those treated with a combination of vitamin D3 and HRC.
Overall, our study indicates that vitamin D3 plays a protective role against lung cancer by downregulating HRC, thus slowing tumor growth and promoting cancer cell death.
We measured the expression of HRC and the vitamin D receptor (VDR) in lung cancer tissues compared to normal and adjacent non-cancerous tissues. Using various lab techniques, we assessed how vitamin D3 affects lung cancer cells, including their growth, spread, and ability to undergo programmed cell death, known as apoptosis.
Our findings revealed that vitamin D3 does inhibit the expression of HRC, which in turn decreased the migration and proliferation of lung cancer cells. Additionally, we noted an increase in the number of cells undergoing apoptosis in response to vitamin D3 treatment. In our animal model, mice treated with a vitamin D3 formulation exhibited smaller tumors and fewer cancerous cells than those treated with a combination of vitamin D3 and HRC.
Overall, our study indicates that vitamin D3 plays a protective role against lung cancer by downregulating HRC, thus slowing tumor growth and promoting cancer cell death.
Read More
9
We explored the potential of aerosolized 1,25-dihydroxyvitamin D3, also known as vitamin D3, to enhance immune responses against lung cancer. This study focused on its ability to shift alveolar macrophages (AM) toward a more cancer-fighting role in the presence of lung metastases from tumors like MC-38 colon carcinoma and B16 melanoma.
By treating AM with vitamin D3, we observed improved stimulation of natural killer (NK) cells, which are crucial for targeting tumor cells. Additionally, when administered in aerosol form directly to the lungs of healthy mouse models, vitamin D3 significantly reduced metastatic growth of cancer cells.
The effects were promising, as our findings indicated that the immune cells in the lungs exhibited greater activation markers and enhanced ability to kill tumor cells when exposed to this treatment. This suggests that targeting vitamin D3 supplementation directly to the lungs could be a novel and effective approach to harness local immunity in combating lung cancer.
By treating AM with vitamin D3, we observed improved stimulation of natural killer (NK) cells, which are crucial for targeting tumor cells. Additionally, when administered in aerosol form directly to the lungs of healthy mouse models, vitamin D3 significantly reduced metastatic growth of cancer cells.
The effects were promising, as our findings indicated that the immune cells in the lungs exhibited greater activation markers and enhanced ability to kill tumor cells when exposed to this treatment. This suggests that targeting vitamin D3 supplementation directly to the lungs could be a novel and effective approach to harness local immunity in combating lung cancer.
Read More
8
We examined how vitamin D3, specifically in its active form 1,25-dihydroxy vitamin D3, influences lung cancer cells, particularly looking at Lewis lung cancer cells. Our research was guided by the question of whether vitamin D3 could affect both the movement of these cancer cells and their metabolism.
Through our analysis, we discovered that 1,25(OH)D treatment led to a significant reduction in the expression and activity of a protein known as Na/H exchanger isoform 1 (NHE1) in lung cancer cells. This protein is crucial for the cells' energy production, particularly through a process called glycolysis.
We observed that with the introduction of vitamin D3, not only was there a suppression of glycolytic enzyme activity—resulting in lower energy production from glucose—but also the overall balance between glycolysis and oxidative phosphorylation (OXPHOS) was shifted. This change helps to discourage cancer cell migration, which is a key factor in metastasis, or the spread of cancer to other parts of the body.
Additionally, our in vivo experiments supported these findings by showing inhibited tumor growth, further validating the potential role of vitamin D3 in combating lung cancer. Together, these results suggest that vitamin D3 could play a vital role in reprogramming cancer cell metabolism and preventing their movement, ultimately serving as a possible therapeutic strategy against lung cancer.
Through our analysis, we discovered that 1,25(OH)D treatment led to a significant reduction in the expression and activity of a protein known as Na/H exchanger isoform 1 (NHE1) in lung cancer cells. This protein is crucial for the cells' energy production, particularly through a process called glycolysis.
We observed that with the introduction of vitamin D3, not only was there a suppression of glycolytic enzyme activity—resulting in lower energy production from glucose—but also the overall balance between glycolysis and oxidative phosphorylation (OXPHOS) was shifted. This change helps to discourage cancer cell migration, which is a key factor in metastasis, or the spread of cancer to other parts of the body.
Additionally, our in vivo experiments supported these findings by showing inhibited tumor growth, further validating the potential role of vitamin D3 in combating lung cancer. Together, these results suggest that vitamin D3 could play a vital role in reprogramming cancer cell metabolism and preventing their movement, ultimately serving as a possible therapeutic strategy against lung cancer.
Read More
Most Useful Reviews
9
Survived cancer
2 people found this helpful
Vitamin D helped me survive Stage 4 metastatic melanoma cancer. I’ve been taking this product for over nine years, and I owe my survival in part to raising my vitamin D levels to 180. At 75 years old, I appreciate the strength it has given me, as shown in the photos of before and after.
Read More
7.5
Improved resilience
8 people found this helpful
No colds! Since having bowel cancer five years ago, I’ve taken a Vitamin D&K supplement and a 5,000IU soft gel D3 daily. I haven’t caught a cold since, attributing this to my consistent intake of these vitamins. In the past, I would get colds at least once a year, but now they seem to pass within a day or two. I believe this increased resilience is due to these supplements. Gotta love it!
Read More
7.5
Maintained levels
I like it! I use this as part of my regimen for cancer treatment. So far, it’s working well; my vitamin D level is stable after taking it for a few years. I’m pleased with the results.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.7
- All Researches
9
We explored the potential role of vitamin D3 in lung cancer patients and its effects on the immune system, specifically focusing on T cells. The research involved 172 patients undergoing treatment for non-small cell lung cancer (NSCLC). These patients received standard chemotherapy and were then given varying doses of vitamin D3 for three weeks.
Our analysis revealed a significant connection between vitamin D levels and immune checkpoint receptors on T cells. Lower levels of vitamin D were associated with higher expressions of exhaustion markers like PD-1 and Tim-3, while higher vitamin D levels correlated with increased CD28 expression, an important marker for T cell activity.
When we looked into the mechanisms of how vitamin D3 works, we found that the active form of vitamin D promotes changes in T cells that help reduce their exhaustion. It does this by influencing specific genes and enhancing T cell function, leading to increased production of Th1 cytokines, which are crucial for effective immune responses against tumors.
Ultimately, we observed that vitamin D3 not only plays a role in improving the function of T cells but also seems to enhance their ability to combat tumor cells in lung cancer patients. This suggests that incorporating vitamin D3 into treatment regimens could potentially improve outcomes for those battling this disease.
Our analysis revealed a significant connection between vitamin D levels and immune checkpoint receptors on T cells. Lower levels of vitamin D were associated with higher expressions of exhaustion markers like PD-1 and Tim-3, while higher vitamin D levels correlated with increased CD28 expression, an important marker for T cell activity.
When we looked into the mechanisms of how vitamin D3 works, we found that the active form of vitamin D promotes changes in T cells that help reduce their exhaustion. It does this by influencing specific genes and enhancing T cell function, leading to increased production of Th1 cytokines, which are crucial for effective immune responses against tumors.
Ultimately, we observed that vitamin D3 not only plays a role in improving the function of T cells but also seems to enhance their ability to combat tumor cells in lung cancer patients. This suggests that incorporating vitamin D3 into treatment regimens could potentially improve outcomes for those battling this disease.
Read More
9
We conducted a study to understand how vitamin D3 influences lung cancer, particularly focusing on a protein known as histidine-rich calcium-binding protein (HRC). Our research explored whether vitamin D3 could help lower HRC levels, given its crucial role in calcium balance, which is significant in cancer development.
We measured the expression of HRC and the vitamin D receptor (VDR) in lung cancer tissues compared to normal and adjacent non-cancerous tissues. Using various lab techniques, we assessed how vitamin D3 affects lung cancer cells, including their growth, spread, and ability to undergo programmed cell death, known as apoptosis.
Our findings revealed that vitamin D3 does inhibit the expression of HRC, which in turn decreased the migration and proliferation of lung cancer cells. Additionally, we noted an increase in the number of cells undergoing apoptosis in response to vitamin D3 treatment. In our animal model, mice treated with a vitamin D3 formulation exhibited smaller tumors and fewer cancerous cells than those treated with a combination of vitamin D3 and HRC.
Overall, our study indicates that vitamin D3 plays a protective role against lung cancer by downregulating HRC, thus slowing tumor growth and promoting cancer cell death.
We measured the expression of HRC and the vitamin D receptor (VDR) in lung cancer tissues compared to normal and adjacent non-cancerous tissues. Using various lab techniques, we assessed how vitamin D3 affects lung cancer cells, including their growth, spread, and ability to undergo programmed cell death, known as apoptosis.
Our findings revealed that vitamin D3 does inhibit the expression of HRC, which in turn decreased the migration and proliferation of lung cancer cells. Additionally, we noted an increase in the number of cells undergoing apoptosis in response to vitamin D3 treatment. In our animal model, mice treated with a vitamin D3 formulation exhibited smaller tumors and fewer cancerous cells than those treated with a combination of vitamin D3 and HRC.
Overall, our study indicates that vitamin D3 plays a protective role against lung cancer by downregulating HRC, thus slowing tumor growth and promoting cancer cell death.
Read More
9
We explored the potential of aerosolized 1,25-dihydroxyvitamin D3, also known as vitamin D3, to enhance immune responses against lung cancer. This study focused on its ability to shift alveolar macrophages (AM) toward a more cancer-fighting role in the presence of lung metastases from tumors like MC-38 colon carcinoma and B16 melanoma.
By treating AM with vitamin D3, we observed improved stimulation of natural killer (NK) cells, which are crucial for targeting tumor cells. Additionally, when administered in aerosol form directly to the lungs of healthy mouse models, vitamin D3 significantly reduced metastatic growth of cancer cells.
The effects were promising, as our findings indicated that the immune cells in the lungs exhibited greater activation markers and enhanced ability to kill tumor cells when exposed to this treatment. This suggests that targeting vitamin D3 supplementation directly to the lungs could be a novel and effective approach to harness local immunity in combating lung cancer.
By treating AM with vitamin D3, we observed improved stimulation of natural killer (NK) cells, which are crucial for targeting tumor cells. Additionally, when administered in aerosol form directly to the lungs of healthy mouse models, vitamin D3 significantly reduced metastatic growth of cancer cells.
The effects were promising, as our findings indicated that the immune cells in the lungs exhibited greater activation markers and enhanced ability to kill tumor cells when exposed to this treatment. This suggests that targeting vitamin D3 supplementation directly to the lungs could be a novel and effective approach to harness local immunity in combating lung cancer.
Read More
8
We examined how vitamin D3, specifically in its active form 1,25-dihydroxy vitamin D3, influences lung cancer cells, particularly looking at Lewis lung cancer cells. Our research was guided by the question of whether vitamin D3 could affect both the movement of these cancer cells and their metabolism.
Through our analysis, we discovered that 1,25(OH)D treatment led to a significant reduction in the expression and activity of a protein known as Na/H exchanger isoform 1 (NHE1) in lung cancer cells. This protein is crucial for the cells' energy production, particularly through a process called glycolysis.
We observed that with the introduction of vitamin D3, not only was there a suppression of glycolytic enzyme activity—resulting in lower energy production from glucose—but also the overall balance between glycolysis and oxidative phosphorylation (OXPHOS) was shifted. This change helps to discourage cancer cell migration, which is a key factor in metastasis, or the spread of cancer to other parts of the body.
Additionally, our in vivo experiments supported these findings by showing inhibited tumor growth, further validating the potential role of vitamin D3 in combating lung cancer. Together, these results suggest that vitamin D3 could play a vital role in reprogramming cancer cell metabolism and preventing their movement, ultimately serving as a possible therapeutic strategy against lung cancer.
Through our analysis, we discovered that 1,25(OH)D treatment led to a significant reduction in the expression and activity of a protein known as Na/H exchanger isoform 1 (NHE1) in lung cancer cells. This protein is crucial for the cells' energy production, particularly through a process called glycolysis.
We observed that with the introduction of vitamin D3, not only was there a suppression of glycolytic enzyme activity—resulting in lower energy production from glucose—but also the overall balance between glycolysis and oxidative phosphorylation (OXPHOS) was shifted. This change helps to discourage cancer cell migration, which is a key factor in metastasis, or the spread of cancer to other parts of the body.
Additionally, our in vivo experiments supported these findings by showing inhibited tumor growth, further validating the potential role of vitamin D3 in combating lung cancer. Together, these results suggest that vitamin D3 could play a vital role in reprogramming cancer cell metabolism and preventing their movement, ultimately serving as a possible therapeutic strategy against lung cancer.
Read More
8
Vitamin D3 may lower lung cancer risk
Our study focused on the effects of vitamin D3 on lung cancer, driven by the question of whether higher intake levels or increased serum levels of 25-hydroxyvitamin D could reduce cancer risk and mortality. We analyzed data from 35 different meta-analyses, which included a total of 59 reports, looking specifically at the relationship between vitamin D and lung cancer outcomes.
The findings were intriguing. We observed that higher vitamin D intake and elevated serum levels were indeed associated with a lower risk of developing cancer. Specifically, when examining instances of lung cancer, we found that a significant reduction in incidence was linked to vitamin D consumption. The odds ratio for lung cancer incidence was reported at 0.88, suggesting that those who have sufficient vitamin D may experience a protective effect.
However, it is essential to note that when we looked exclusively at randomized controlled trials, the data did not show a significant connection between vitamin D intake and lung cancer risk. This suggests that while there may be promising observations in some studies, more rigorously designed research is necessary to draw definitive conclusions about vitamin D3 as an effective treatment for lung cancer.
Overall, while our exploration highlighted some potential benefits of vitamin D related to lung cancer, it's clear that careful consideration is needed when interpreting these results and their implications.
The findings were intriguing. We observed that higher vitamin D intake and elevated serum levels were indeed associated with a lower risk of developing cancer. Specifically, when examining instances of lung cancer, we found that a significant reduction in incidence was linked to vitamin D consumption. The odds ratio for lung cancer incidence was reported at 0.88, suggesting that those who have sufficient vitamin D may experience a protective effect.
However, it is essential to note that when we looked exclusively at randomized controlled trials, the data did not show a significant connection between vitamin D intake and lung cancer risk. This suggests that while there may be promising observations in some studies, more rigorously designed research is necessary to draw definitive conclusions about vitamin D3 as an effective treatment for lung cancer.
Overall, while our exploration highlighted some potential benefits of vitamin D related to lung cancer, it's clear that careful consideration is needed when interpreting these results and their implications.
Read More
User Reviews
USERS' SCORE
Good
Based on 7 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Survived cancer
2 people found this helpful
Vitamin D helped me survive Stage 4 metastatic melanoma cancer. I’ve been taking this product for over nine years, and I owe my survival in part to raising my vitamin D levels to 180. At 75 years old, I appreciate the strength it has given me, as shown in the photos of before and after.
Read More
7.5
Improved resilience
8 people found this helpful
No colds! Since having bowel cancer five years ago, I’ve taken a Vitamin D&K supplement and a 5,000IU soft gel D3 daily. I haven’t caught a cold since, attributing this to my consistent intake of these vitamins. In the past, I would get colds at least once a year, but now they seem to pass within a day or two. I believe this increased resilience is due to these supplements. Gotta love it!
Read More
7.5
Maintained levels
I like it! I use this as part of my regimen for cancer treatment. So far, it’s working well; my vitamin D level is stable after taking it for a few years. I’m pleased with the results.
Read More
7.5
Boosted immunity
A must-have for immunity, especially for those lacking sunlight! Vitamin D is effective in preventing cancer, so it’s important to maintain levels to enhance immune function.
Read More
7.5
Reduced cell growth
This product is excellent, including K1, K2 and Iodine. Vitamin D3 aids calcium absorption, reduces inflammation, and has been shown to decrease cancer cell growth. K2 ensures calcium is shuttled to bones effectively. It’s an outstanding supplement, especially for the price!
Read More
Frequently Asked Questions
9
Survived cancer
2 people found this helpful
Vitamin D helped me survive Stage 4 metastatic melanoma cancer. I’ve been taking this product for over nine years, and I owe my survival in part to raising my vitamin D levels to 180. At 75 years old, I appreciate the strength it has given me, as shown in the photos of before and after.
7.5
Maintained levels
I like it! I use this as part of my regimen for cancer treatment. So far, it’s working well; my vitamin D level is stable after taking it for a few years. I’m pleased with the results.
7.5
Improved resilience
8 people found this helpful
No colds! Since having bowel cancer five years ago, I’ve taken a Vitamin D&K supplement and a 5,000IU soft gel D3 daily. I haven’t caught a cold since, attributing this to my consistent intake of these vitamins. In the past, I would get colds at least once a year, but now they seem to pass within a day or two. I believe this increased resilience is due to these supplements. Gotta love it!
7.5
Reduced cell growth
This product is excellent, including K1, K2 and Iodine. Vitamin D3 aids calcium absorption, reduces inflammation, and has been shown to decrease cancer cell growth. K2 ensures calcium is shuttled to bones effectively. It’s an outstanding supplement, especially for the price!
7.5
Boosted immunity
A must-have for immunity, especially for those lacking sunlight! Vitamin D is effective in preventing cancer, so it’s important to maintain levels to enhance immune function.
7.5
Regulated growth
This vitamin D is from a top manufacturer and has been proven to function like a hormone. It promotes muscle tone, increases immunity, and aids thyroid function. Vitamin D helps protect nerve sheaths and regulates blood pressure, preventing the growth of cancer cells. I recommend taking it year-round in a small dosage of 1000, with the right balance of vitamin K for best absorption.
8
We examined how vitamin D3, specifically in its active form 1,25-dihydroxy vitamin D3, influences lung cancer cells, particularly looking at Lewis lung cancer cells. Our research was guided by the question of whether vitamin D3 could affect both the movement of these cancer cells and their metabolism.
Through our analysis, we discovered that 1,25(OH)D treatment led to a significant reduction in the expression and activity of a protein known as Na/H exchanger isoform 1 (NHE1) in lung cancer cells. This protein is crucial for the cells' energy production, particularly through a process called glycolysis.
We observed that with the introduction of vitamin D3, not only was there a suppression of glycolytic enzyme activity—resulting in lower energy production from glucose—but also the overall balance between glycolysis and oxidative phosphorylation (OXPHOS) was shifted. This change helps to discourage cancer cell migration, which is a key factor in metastasis, or the spread of cancer to other parts of the body.
Additionally, our in vivo experiments supported these findings by showing inhibited tumor growth, further validating the potential role of vitamin D3 in combating lung cancer. Together, these results suggest that vitamin D3 could play a vital role in reprogramming cancer cell metabolism and preventing their movement, ultimately serving as a possible therapeutic strategy against lung cancer.
Through our analysis, we discovered that 1,25(OH)D treatment led to a significant reduction in the expression and activity of a protein known as Na/H exchanger isoform 1 (NHE1) in lung cancer cells. This protein is crucial for the cells' energy production, particularly through a process called glycolysis.
We observed that with the introduction of vitamin D3, not only was there a suppression of glycolytic enzyme activity—resulting in lower energy production from glucose—but also the overall balance between glycolysis and oxidative phosphorylation (OXPHOS) was shifted. This change helps to discourage cancer cell migration, which is a key factor in metastasis, or the spread of cancer to other parts of the body.
Additionally, our in vivo experiments supported these findings by showing inhibited tumor growth, further validating the potential role of vitamin D3 in combating lung cancer. Together, these results suggest that vitamin D3 could play a vital role in reprogramming cancer cell metabolism and preventing their movement, ultimately serving as a possible therapeutic strategy against lung cancer.
9
We explored the potential role of vitamin D3 in lung cancer patients and its effects on the immune system, specifically focusing on T cells. The research involved 172 patients undergoing treatment for non-small cell lung cancer (NSCLC). These patients received standard chemotherapy and were then given varying doses of vitamin D3 for three weeks.
Our analysis revealed a significant connection between vitamin D levels and immune checkpoint receptors on T cells. Lower levels of vitamin D were associated with higher expressions of exhaustion markers like PD-1 and Tim-3, while higher vitamin D levels correlated with increased CD28 expression, an important marker for T cell activity.
When we looked into the mechanisms of how vitamin D3 works, we found that the active form of vitamin D promotes changes in T cells that help reduce their exhaustion. It does this by influencing specific genes and enhancing T cell function, leading to increased production of Th1 cytokines, which are crucial for effective immune responses against tumors.
Ultimately, we observed that vitamin D3 not only plays a role in improving the function of T cells but also seems to enhance their ability to combat tumor cells in lung cancer patients. This suggests that incorporating vitamin D3 into treatment regimens could potentially improve outcomes for those battling this disease.
Our analysis revealed a significant connection between vitamin D levels and immune checkpoint receptors on T cells. Lower levels of vitamin D were associated with higher expressions of exhaustion markers like PD-1 and Tim-3, while higher vitamin D levels correlated with increased CD28 expression, an important marker for T cell activity.
When we looked into the mechanisms of how vitamin D3 works, we found that the active form of vitamin D promotes changes in T cells that help reduce their exhaustion. It does this by influencing specific genes and enhancing T cell function, leading to increased production of Th1 cytokines, which are crucial for effective immune responses against tumors.
Ultimately, we observed that vitamin D3 not only plays a role in improving the function of T cells but also seems to enhance their ability to combat tumor cells in lung cancer patients. This suggests that incorporating vitamin D3 into treatment regimens could potentially improve outcomes for those battling this disease.
8
Vitamin D3 may lower lung cancer risk
Our study focused on the effects of vitamin D3 on lung cancer, driven by the question of whether higher intake levels or increased serum levels of 25-hydroxyvitamin D could reduce cancer risk and mortality. We analyzed data from 35 different meta-analyses, which included a total of 59 reports, looking specifically at the relationship between vitamin D and lung cancer outcomes.
The findings were intriguing. We observed that higher vitamin D intake and elevated serum levels were indeed associated with a lower risk of developing cancer. Specifically, when examining instances of lung cancer, we found that a significant reduction in incidence was linked to vitamin D consumption. The odds ratio for lung cancer incidence was reported at 0.88, suggesting that those who have sufficient vitamin D may experience a protective effect.
However, it is essential to note that when we looked exclusively at randomized controlled trials, the data did not show a significant connection between vitamin D intake and lung cancer risk. This suggests that while there may be promising observations in some studies, more rigorously designed research is necessary to draw definitive conclusions about vitamin D3 as an effective treatment for lung cancer.
Overall, while our exploration highlighted some potential benefits of vitamin D related to lung cancer, it's clear that careful consideration is needed when interpreting these results and their implications.
The findings were intriguing. We observed that higher vitamin D intake and elevated serum levels were indeed associated with a lower risk of developing cancer. Specifically, when examining instances of lung cancer, we found that a significant reduction in incidence was linked to vitamin D consumption. The odds ratio for lung cancer incidence was reported at 0.88, suggesting that those who have sufficient vitamin D may experience a protective effect.
However, it is essential to note that when we looked exclusively at randomized controlled trials, the data did not show a significant connection between vitamin D intake and lung cancer risk. This suggests that while there may be promising observations in some studies, more rigorously designed research is necessary to draw definitive conclusions about vitamin D3 as an effective treatment for lung cancer.
Overall, while our exploration highlighted some potential benefits of vitamin D related to lung cancer, it's clear that careful consideration is needed when interpreting these results and their implications.
References
- Wierzbicka A, Semik-Gurgul E, Świątkiewicz M, Szmatoła T, Steg A, et al. Changes in DNA Methylation and mRNA Expression in Lung Tissue after Long-Term Supplementation with an Increased Dose of Cholecalciferol. Int J Mol Sci. 2023;25. 10.3390/ijms25010464
- Chen H, Zhu MZ, Wang XT, Ai M, Li SS, et al. 1,25(OH) D inhibits Lewis lung cancer cell migration via NHE1-sensitive metabolic reprograming. IUBMB Life. 2024;76:182. 10.1002/iub.2789
- Arayici ME, Basbinar Y, Ellidokuz H. Vitamin D Intake, Serum 25-Hydroxyvitamin-D (25(OH)D) Levels, and Cancer Risk: A Comprehensive Meta-Meta-Analysis Including Meta-Analyses of Randomized Controlled Trials and Observational Epidemiological Studies. Nutrients. 2023;15. 10.3390/nu15122722
- Li P, Zhu X, Cao G, Wu R, Li K, et al. 1α,25(OH)D reverses exhaustion and enhances antitumor immunity of human cytotoxic T cells. J Immunother Cancer. 2022;10. 10.1136/jitc-2021-003477
- Jia Z, Wang K, Duan Y, Hu K, Zhang Y, et al. Claudin1 decrease induced by 1,25-dihydroxy-vitamin D3 potentiates gefitinib resistance therapy through inhibiting AKT activation-mediated cancer stem-like properties in NSCLC cells. Cell Death Discov. 2022;8:122. 10.1038/s41420-022-00918-5
- Yiyan S, Yang S, Li D, Li W. Vitamin D Affects the Warburg Effect and Stemness Maintenance of Non- Small-Cell Lung Cancer Cells by Regulating the PI3K/AKT/mTOR Signaling Pathway. Curr Cancer Drug Targets. 2022;22:86. 10.2174/1568009621666210729100300
- Lawson C, Ferreira V, Carli F, Chevalier S. Effects of multimodal prehabilitation on muscle size, myosteatosis, and dietary intake of surgical patients with lung cancer - a randomized feasibility study. Appl Physiol Nutr Metab. 2021;46:1407. 10.1139/apnm-2021-0249
- Ai M, Li SS, Chen H, Wang XT, Sun JN, et al. 1,25(OH) D attenuates sleep disturbance in mouse models of Lewis lung cancer, in silico and in vivo. J Cell Physiol. 2021;236:7473. 10.1002/jcp.30458
- Liu N, Li X, Fu Y, Li Y, Lu W, et al. Inhibition of lung cancer by vitamin D depends on downregulation of histidine-rich calcium-binding protein. J Adv Res. 2021;29:13. 10.1016/j.jare.2020.08.013
- Bianchi F, Sommariva M, Le Noci V, Camelliti S, Gagliano N, et al. Aerosol 1,25-dihydroxyvitamin D3 supplementation: A strategy to boost anti-tumor innate immune activity. PLoS One. 2021;16:e0248789. 10.1371/journal.pone.0248789
- Maj E, Maj B, Bobak K, Gos M, Chodyński M, et al. Differential Response of Lung Cancer Cells, with Various Driver Mutations, to Plant Polyphenol Resveratrol and Vitamin D Active Metabolite PRI-2191. Int J Mol Sci. 2021;22. 10.3390/ijms22052354
